Journal
EXPERIMENTAL PARASITOLOGY
Volume 123, Issue 1, Pages 58-64Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2009.05.012
Keywords
Leishmania; Apoptosis; Macrophage
Categories
Funding
- National Institutes of Health [A1056242]
- American Heart Association [043533Z]
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Activation of apoptosis is one of the most ancient mechanisms to eliminate intracellular infections; the capacity to subvert this programed cell death provides an adaptive advantage to pathogens that persist in an intracellular environment. Leishmania species are obligate intracellular parasites that primarily reside within host macrophages. We demonstrate here that Leishmania infection protects macrophages from cycloheximide-induced apoptosis in a species and strain specific manner. Our data further reveal that Leishmania phosphoglycans and direct contact between parasites and host cells are required for the inhibitory phenotype. (C) 2009 Elsevier Inc. All rights reserved.
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