Journal
EXPERIMENTAL PARASITOLOGY
Volume 123, Issue 3, Pages 203-211Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2009.07.015
Keywords
Trematode; Schistosoma mansoni infection; Juvenile Biomphalaria glabrata; Susceptible; Resistant; Non-susceptible; Stress response; Irradiation; Miracidia; Heat shock protein 70; Reverse transcriptase
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Funding
- NIH-NIAID [R01-AI63480]
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Schistosomes develop successfully in susceptible snails but are encapsulated and killed in resistant ones. Mechanism(s) shaping these outcomes involves the parasites ability to evade the snail's defenses. RNA analysis from resistant (BS-90), non-susceptible (LAC2) and susceptible (NMRI) juvenile Biomphalaria glabrata to Schistosoma mansoni revealed that stress-related genes, heat shock protein 70 (Hsp 70) and reverse transcriptase (RT), were dramatically co-induced early in susceptible snails, but not in resistant/non-susceptible ones. These transcripts were, however, down regulated upon exposure to irradiated parasites although penetration behavior of irradiated vs. normal parasites were the same, indicating that Hsp 70 and RT regulation was elicited by infection and not injury. Understanding molecular events involved in stress response transcriptional regulation of Hsp 70 in juvenile snails could pave a way towards the identification of genes involved in schistosome/snail interactions. (C) 2009 Elsevier Inc. All rights reserved.
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