Journal
EXPERIMENTAL PARASITOLOGY
Volume 119, Issue 1, Pages 67-73Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2007.12.016
Keywords
blood groups; chemoattraction
Categories
Ask authors/readers for more resources
The role of exposed surface carbohydrates in chemoreception in Schistosoma mansoni females was investigated in vitro. Sexually mature females were treated with peanut (PNA), soybean (SBA) or wheat germ (WGA) agglutinin, and their migration in response to excretory-secretory (ES) products of males was measured in a bioassay system. Random distribution of untreated and lectin-treated females was similar (p = >0.05). PNA-treated females were unresponsive for 1.0 h, after which they exhibited slight repulsion to ES products. SBA-treated females did not respond to ES products for 3.0 h. WGA-treated females were unresponsive for 1.5 h, after which they exhibited slight attraction to male ES products. Attempts were made to restore chemoattraction by using specific sugar inhibitors of lectin-binding; chemoattraction was best restored in n-acetyl-D-galactosamine (GaINAe)-treated females. These data suggest that GaINAc-containing receptors, possibly GP50, the major SBA-binding schistosome glycan, mediate chemoreception in schistosome females. These findings may explain the observed differences in morbidity between individuals with different blood groups. Individuals with blood group B or 0 may afford partial protection because of their natural anti-A or by mounting a more efficient antibody response directed against GaINAc-containing structures shared by blood group A red blood cells. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available