Journal
EXPERIMENTAL NEUROLOGY
Volume 262, Issue -, Pages 91-101Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2014.04.013
Keywords
Amyotrophic lateral sclerosis; Heritability; Genetic factors; Rare disease; Whole exome sequencing
Categories
Funding
- ALS from Canadian Institutes of Health
- Muscular Dystrophy Association ALS Division
- ALS Association
- ALS Society of Canada
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Amyotrophic lateral sclerosis (ALS) is a fatal late onset neurological disorder characterized by motor neuron degeneration in the primary motor cortex, brainstem and spinal cord. The majority of cases are sporadic (SALS) and only 5-10% have a family history (FALS). FALS cases show a high heritability and this has enabled the identification of several genetic triggers, of which mutations in SOD1, FUS, TARDBP and C90RF72 are the most frequent. While such advances have contributed to our current understanding of the causes of most cases of FALS and their underlying pathophysiological consequences, they only explain a small fraction of SALS with the etiology of most SALS cases remaining unexplained. Here, we review past and current methods used for the identification of FALS and SALS associated genes and propose a risk-based classification for these. We also discuss how the growing number of whole exome/genome sequencing datasets prepared from SALS cases, and control individuals, may reveal novel insights into the genetic etiology of SALS; for instance through revealing increased mutation burden rates across genes or genomic regions that were not previously associated with ALS or through allowing the examination of a potential oligogenic mechanism of the disease. Finally we summarize the three most recently discovered 'high risk' genes in ALS. (C) 2014 Elsevier Inc. All rights reserved.
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