Journal
EXPERIMENTAL NEUROLOGY
Volume 260, Issue -, Pages 50-55Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2014.04.027
Keywords
Stem cell; Precursor cell; Progenitor cell; Multipotent; Oligodendrocyte; Regeneration; Remyelination; Schwann cell; Astrocyte; Neuron
Categories
Funding
- Wellcome Trust Veterinary Integrated Training Fellowship
- Wellcome Trust [100269/Z/12/Z] Funding Source: Wellcome Trust
- MRC [G0800575] Funding Source: UKRI
- Medical Research Council [G0800575] Funding Source: researchfish
- Wellcome Trust [100269/Z/12/Z] Funding Source: researchfish
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Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the capacity to differentiate into mature, myelinating oligodendrocytes. The name 'oligodendrocyte progenitor' suggests restriction to the oligodendrocyte cell lineage. However, with growing evidence of the lineage plasticity of OPs both in vitro and in vivo, we discuss whether they have potential beyond that expected of dedicated progenitor cells, and hence may justify categorization as adult stem cells. (C) 2014 Elsevier Inc. All rights reserved.
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