Journal
EXPERIMENTAL NEUROLOGY
Volume 251, Issue -, Pages 30-38Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2013.10.019
Keywords
Cross-frequeney coupling; Epilepsy; High frequency oscillations; HFOs; Seizure; Intracranial EEG; Networks
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Funding
- Canadian Institutes of Health Research (CIHR) Vanier Canada Graduate Scholarship
- CIHR Bisby Fellowship
- Hospital for Sick Children Foundation Student Scholarship Program
- Hospital for Sick Children Centre for Brain and Behaviour
- EpLink program of the Ontario Brain Institute
- Wiley Family Fund for Epilepsy Surgery Research
- Jack Beqaj Fund for Epilepsy Surgery Research
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Pathological high frequency oscillations (pHFOs) have been proposed to be robust markers of epileptic cortex. Oscillatory activity below this frequency range has been shown to be modulated by phase of lower frequency oscillations. Here, we tested the hypothesis that dynamic cross-frequency interactions involving pHFOs are concentrated within the epileptogenic cortex. Intracranial electroencephalographic recordings from 17 children with medically-intractable epilepsy secondary to focal cortical dysplasia were obtained. A time-resolved analysis was performed to determine topographic concentrations and dynamic changes in cross-frequency amplitude-to-phase coupling (CFC). CFC between pHFOs and the phase of theta and alpha rhythms was found to be significantly elevated in the seizure-onset zone compared to non-epileptic regions (p < 0.01). Data simulations showed that elevated CFC could not be attributed to the presence of sharp transients or other signal properties. The phase of low frequency oscillations at which pHFO amplitudes were maximal was inconsistent at seizure initiation, yet consistently at the trough of the low frequency rhythm at seizure termination. Amplitudes of pHFOs were most significantly modulated by the phase of alpha-band oscillations (p < 0.01). These results suggest that increased CFC between pHFO amplitude and alpha phase may constitute a marker of epileptogenic brain areas and may be relevant for understanding seizure dynamics. (C) 2013 Elsevier Inc All rights reserved.
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