Journal
EXPERIMENTAL NEUROLOGY
Volume 247, Issue -, Pages 744-747Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2013.02.005
Keywords
Neuromyelitis optica; Type I IFN; Aquaporin-4; Astrocytes; Inflammation
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Funding
- Danish Agency for Science Technology and Innovation
- Danish Multiple Sclerosis Society
- Region of Southern Denmark
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Neuromyelitis optica is an antibody-mediated autoimmune inflammatory disease of the central nervous system. Reports have suggested that interferon beta which is beneficial for multiple sclerosis, exacerbates neuromyelitis optics. Our aim was to determine whether type I interferon plays a role in the formation of neuromyelitis optica lesions. Immunoglobulin G from a neuromyelitis optica patient was injected intracerebrally with human complement to type I interferon receptor deficient and wildtype mice. Loss of aquaporin-4 and glial fibrillary acidic protein was reduced in type I interferon receptor deficient mice brain. Our findings suggest that type I interferon signaling contributes to neuromyelitis optics pathogenesis. (C) 2013 Elsevier Inc. All rights reserved.
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