Journal
EXPERIMENTAL NEUROLOGY
Volume 223, Issue 1, Pages 1-4Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2009.12.001
Keywords
Peripheral nerve regeneration; Conditioning lesion; Preferential motor reinnervation; Chronic denervation; Schwann cell
Categories
Funding
- NINDS NIH HHS [R01 NS034484, R01 NS034484-13] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034484] Funding Source: NIH RePORTER
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Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration. (C) 2009 Elsevier Inc. All rights reserved.
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