Journal
EXPERIMENTAL NEUROLOGY
Volume 225, Issue 1, Pages 231-236Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2010.06.006
Keywords
Rats; Fetal spinal cord; Ventilation; Phrenic; Transplantation; Respiratory; Cervical spinal cord injury
Categories
Funding
- NIH NINDS [RO1NS054025]
- Anne and Oscar Lackner Chair in Medicine
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Despite extensive gray matter loss following spinal cord injury (SCI), little attention has been given to neuronal replacement strategies and their effects on specific functional circuits in the injured spinal cord. In the present study, we assessed breathing behavior and phrenic nerve electrophysiological activity following transplantation of microdissected dorsal or ventral pieces of rat fetal spinal cord tissue (FSCD or FSCV, respectively) into acute, cervical (C2) spinal hemisections. Transneuronal tracing demonstrated connectivity between donor neurons from both sources and the host phrenic circuitry. Phrenic nerve recordings revealed differential effects of dorsally vs. ventrally derived neural progenitors on ipsilateral phrenic nerve recovery and activity. These initial results suggest that local gray matter repair can influence motoneuron function in targeted circuits following spinal cord injury and that outcomes will be dependent on the properties and phenotypic fates of the donor cells employed. (C) 2010 Elsevier Inc. All rights reserved.
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