Transient elevation of adult hippocampal neurogenesis after dopamine depletion

Degeneration of the midbrain dopaminergic neurons during Parkinson's disease (PD) may affect remote regions of the brain that are innervated by the projections of these neurons The dentate gyrus (DG). a site of continuous production of new neurons in the adult hippocampus, receives dopaminergic Inputs from the neurons of the substantia nigra (SN) Thus, depletion of the SN neurons during disease or in experimental settings may directly affect adult hippocampal neurogenesis We show that experimental ablation of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydopyridine (MPTP) mouse model of PD results in a transient increase in cell division in the subgranular zone (SGZ) of the DG This increase is evident for the amplifying neural piogenitors and for their postmitotic progeny, our results ASO indicate that MPTP treatment affects division of the normally quiescent stern cells in the SGZ We also show that L-DOPA, Used in the clinical treatment of PD, while attenuating the MPTP-induced death of clopaminergic neurons. does not alter the effect of MPTP oil cell division in the DC Our results suggest that a decrease in cloparrunergic signaling in the hippocamPUS leads to a transient activation of stern and progenitor cells in the DG (C) 2010 Elsevier Inc All rights reserved