Journal
EXPERIMENTAL NEUROLOGY
Volume 218, Issue 2, Pages 347-352Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2009.03.007
Keywords
Apoptosis; Mitochondria membrane permeabilization; Caspase; AIF; Apaf-1; Cytochrome c; Retina
Categories
Funding
- Ligue Nationale contre le Cancer (Equipe labellisee)
- European Commission
- Canceropole Ile-de-France
- Fondation de France
- Fondation pour la Recherche Medicale
Ask authors/readers for more resources
Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the point of no return of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available