Journal
EXPERIMENTAL NEUROLOGY
Volume 213, Issue 1, Pages 241-244Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2008.06.003
Keywords
neurotransplantation; fetal striatal tissue; Huntington's disease; neuroblasts; restoration
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Replacement of damaged neuronal Population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent Success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This Study represents the first in vivo demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma. (C) 2008 Elsevier Inc. All rights reserved.
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