Journal
EXPERIMENTAL NEUROLOGY
Volume 209, Issue 2, Pages 343-352Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2007.05.027
Keywords
integrin receptors; rac; rho and ras GTPase; growth cone; motility; chondroitin sulfate proteoglycans; CSPGs; semaphorin; FAK; guidance
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Funding
- NINDS NIH HHS [R01 NS 48382, R01 NS048382-05] Funding Source: Medline
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The inability of the adult injured mammalian spinal cord to successfully regenerate is not well understood. Studies suggest that both extrinsic and intrinsic factors contribute to regeneration failure. In this review, we focus on intrinsic factors that impact regeneration, in particular integrin receptors and their downstream signaling pathways. We discuss studies that address the impact of integrins and integrin signaling pathways on growth cone guidance and motility and how lessons learned from these studies apply to spinal cord regeneration in vivo. (C) 2007 Elsevier Inc. All rights reserved.
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