Journal
EXPERIMENTAL LUNG RESEARCH
Volume 38, Issue 4, Pages 165-172Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/01902148.2011.654045
Keywords
5 alpha-DHT; 17 beta-estradiol; ozone; pneumonia; sex differences; surfactant protein-A
Categories
Funding
- National Institute of Environmental Health Sciences [ES09882]
- Children's Miracle Network at Penn State College of Medicine
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Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence of ozone (O-3) exposure prior to infection, is sex dependent. The objective of this work was to study the role of gonadal hormones, 5 alpha-dihydrotestosterone (DHT) and 17 beta-estradiol (E-2), on mouse survival after filtered air (FA) or O-3 exposure. Gonadectomized female (GxF) and male (GxM) mice implanted with control or hormone pellets (DHT in GxF, or E-2 in GxM), exposed to O-3 (2 ppm, 3h) or FA, and infected with K. pneumoniae were monitored for survival. Survival in GxF was identical after FA or O-3 exposure; in GxM O-3 exposure resulted in lower survival compared to FA. In O-3-exposed females, gonadectomy resulted in increased survival compared to intact females or to GxM+E-2. A similar effect was observed in GxF+DHT. The combined negative effect of oxidative stress and hormone on survival was higher for E-2. Gonadectomy eliminated (females) or minimized (males) the previously observed sex differences in survival in response to oxidative stress, and hormone treatment restored them. These findings indicate that gonadal hormones and/or oxidative stress have a significant effect on mouse survival.
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