Journal
EXPERIMENTAL LUNG RESEARCH
Volume 36, Issue 4, Pages 201-210Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/01902140903290022
Keywords
cyclin D1; human airway smooth muscle cell (HASMCs); passively sensitized; proliferation; protein kinase C alpha (PKC alpha)
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Funding
- National Natural Sciences Foundation of China [30670925]
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Abnormal hypertrophy and hyperplasia of airway smooth muscle cells play an important role in airway remodeling in chronic asthma. The authors' previous studies have indicated that protein kinase C alpha (PKC alpha) is involved in the proliferation of passively sensitized human airway smooth muscle cells (HASMCs). However, the underlying mechanisms remain unknown. Here, the authors examined the possible role of the alpha isoform of PKC in the control of cyclin D1 expression, using HASMCs passively sensitized on human atopic asthmatic serum as a model system. Cultured HASMCs were passively sensitized with serum from atopic asthmatic patients. Cell proliferation was measured by [
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