Journal
EXPERIMENTAL LUNG RESEARCH
Volume 35, Issue 5, Pages 427-438Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140902747436
Keywords
lung; oxidative stress; vitamin A
Categories
Funding
- CNPq
- CAPES
- FAPERGS
- PROPESQ/UFRGS (Brazil)
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Lungs require an adequate supply of vitamin A for normal embtyonic development, postnatal, maturation, and maintenance andrepair during adult life. However, recent intervention studies revealed that supplementation with retinoids resulted in a higher incidence of lung cancer, although the mechanisms underlying this effect are still unknown. Here, the authors,studied the effect of vitamin A supplementation on oxidative stress parameters in lungs of Wistar rats. Vitamin A supplementation either at therapeutic (1000 and 2500 IU/kg) or excessive (4500 and 9000 IU/kg) doses for 28 days induced lipid peroxidation, protein carbonylation, and oxidation of protein thiol groups, as well as change in catalase (EC 1.11.1.6; CAT) and superoxide dismutase (EC 1.15.1.1, SOD) activities and immunocontents. These results altogether suggest that vitamin A supplementation causes significant changes in redox balance the free radical status in lungs, which are frequently associated to severe lung dysfunction.
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