Journal
EXPERIMENTAL LUNG RESEARCH
Volume 35, Issue 5, Pages 371-379Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140902718536
Keywords
lung; hyperglycemia; nitrosative/oxidative stress; pioglitazone; repaglinide
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The lungs are involved in diabetes in the cause of the complex phenomena diabetes generates. In the present study, hyperglycemia inhibited pulmonary antioxidants, including superoxide dismutase, catalase, glutathione peroxidase, and glutathione. These effects were accompanied by significant elevation of lipid peroxidation, total nitrites, and nitrotyrosine Levels. The study investigated the effects of 2 oral antidiabetics, pioglitazone and repaglinide, on the mentioned parameters. It is concluded that pioglitazone exerts Protective effect in the lung by inhibiting nitrosative stress and normalizing the nitrites and nitrotyrosine Levels. Administration, of repaglinide prevents oxidative and, to a smaller extent, nitrosative changes.
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