Journal
EXPERIMENTAL LUNG RESEARCH
Volume 34, Issue 5, Pages 263-275Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140802022518
Keywords
phagocytosis; prostaglandin; P. aeruginosa
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Funding
- NIAID NIH HHS [R01 AI065543, R01 AI065543-03, T32 AI007413, R01 AI065543-03S1, T32AI065543, R56 AI065543] Funding Source: Medline
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The authors compared efficiency of alveolar macrophage (AM) reconstitution from donor bone marrow Post transplant following 4 chemotherapy conditioning regimens and 2 total body irradiation (TBI) regimens. TBI regimens are more effective in inducing AM reconstitution from donor marrow. However mire conditioned with 13 Gy split-dose TBI or a dual-chemotherapy regimen (25 mg/kg busu fan x 4 days plus cyclophosphamide 100 mg/kg x 2 days) both demonstrate significant AM repopulation from donor marrow. Additionally, both protocols resulted in impaired pulmonary host defense associated with overproduction of prostaglandin E-2 and I-2 by AMs and impaired AM phagocylosis post bone marrow transplant.
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