Journal
EXPERIMENTAL GERONTOLOGY
Volume 54, Issue -, Pages 47-52Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2013.12.009
Keywords
IFN-I; IFN-III; NF-kB; T cell priming; mDC; pDC
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Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs. (c) 2014 Elsevier Inc. All rights reserved.
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