Journal
EXPERIMENTAL GERONTOLOGY
Volume 47, Issue 12, Pages 919-924Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.08.001
Keywords
Prion protein; Epidemiological study; Homo sapiens; Cognition; Executive function
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Funding
- Baden-Wurttemberg Ministry of Research, Science and Arts
- Marsilius Kolleg, Center of Advanced Studies, University of Heidelberg
- Federal Ministry for Education and Research (BMBF)
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Objectives: Recent animal studies have suggested a key role for cellular prion protein (PrPc) in the pathological consequences of amyloid plaque formation, the hallmark of Alzheimer's disease. This epidemiological study investigated whether serum concentrations of PrPc are associated with cognitive functioning in humans. Design, Setting, Participants: Cross-sectional study of 1,322 participants from the elderly general population in Germany, aged 65 + years at baseline (2000-2002). Measurements: Cognitive functioning was assessed by the COGTEL phone interview 5 years after baseline. Serum PrPc was determined by a commercial immunoassay. Results: In multiple linear regression adjusted for important confounders, subjects in higher PrPc quintiles appeared to have lower cognitive functioning scores than those in the lowest PrPc quintile. Spline regression suggested pronounced non-linearity with an inverse association between PrPc and cognitive functioning levelling off beyond median PrPc. Cognitive subdomain-specific models produced somewhat heterogeneous results. Conclusion: The findings are suggestive of an independent association of PrPc with cognitive functioning in humans. Confirmatory and longitudinal studies are needed to elucidate the potential of PrPc for applications in early risk stratification for cognitive impairment. (C) 2012 Elsevier Inc. All rights reserved.
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