Journal
EXPERIMENTAL GERONTOLOGY
Volume 45, Issue 4, Pages 255-268Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2009.12.013
Keywords
Epigenetic; DNA methylation; Chromatin; Aging; Microarray
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD044078] Funding Source: NIH RePORTER
- NICHD NIH HHS [R01 HD044078-04, R01 HD044078] Funding Source: Medline
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In this review, we describe how normal ageing may involve the acquisition of epigenetic errors over time, akin to the accumulation of genetic mutations with ageing. We describe how such experiments are currently performed, their limitations technically and analytically and their application to ageing research. (C) 2010 Elsevier Inc. All rights reserved.
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