Journal
EXPERIMENTAL GERONTOLOGY
Volume 44, Issue 1-2, Pages 106-111Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2008.05.003
Keywords
Actin; Myosin; Aged muscle; Enzymatic activity; oxidative modifications
Categories
Funding
- NIA NIH HHS [R01 AG017768] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG017768] Funding Source: NIH RePORTER
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Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to highlight cellular, molecular, and biochemical changes that contribute to age-related muscle dysfunction. (c) 2008 Elsevier Inc. All rights reserved.
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