Journal
EXPERIMENTAL EYE RESEARCH
Volume 93, Issue 4, Pages 331-339Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2011.08.007
Keywords
glaucoma; POAG; XFG; PCG; CDKN2B; SIX1; CAV1; LOXL1
Categories
Funding
- NEI NIH HHS [R01 EY019126, R01 EY013315] Funding Source: Medline
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Glaucoma is a family of diseases whose pathology is defined by the progressive loss of retinal ganglion cells. Clinically, glaucoma presents as a distinctive optic neuropathy with associated visual field loss. Primary open-angle glaucoma (POAG), chronic angle-closure glaucoma (ACG), and exfoliation glaucoma (XFG) are the most prevalent forms of glaucoma globally and are the most common causes of glaucoma-related blindness worldwide. A host of genetic and environmental factors contribute to glaucoma phenotypes. This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma (PCG), the developmental glaucomas, and pigment dispersion glaucoma. (C) 2011 Elsevier Ltd. All rights reserved.
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