Journal
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
Volume 9, Issue 2, Pages 86-96Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2014.11.008
Keywords
Hypertension; obesity; pregnancy; HELLP syndrome
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Funding
- BRAHMS GmbH
- Region of Southern Denmark
- A.J. Andersen's Foundation
- A.P. Moeller Maersk Foundation for Medical Science
- Odense University Hospital
- Strategic Research Council of Denmark
- Novo Nordisk Fonden [NNF13OC0006975] Funding Source: researchfish
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The angiogenic factor ratio soluble Fms-kinase 1 (sFlt-1)/placental growth factor (PlGF) is a novel diagnostic tool for pre-eclampsia. We compared the efficacy of the KRYPTOR (BRAHMS) automated assays for sFlt-1 and PlGF with the Elecsys (Roche) assays in a routine clinical setting. Preeclamptic women (n = 39) were included shortly after the time of diagnosis. Normotensive control pregnancies were matched by gestational age (n = 76). The KRYPTOR assays performed comparably or superior to Elecsys (sFlt-1/PlGF area under the curve 0.746 versus 0.735; P = .09; for non obese 0.820 versus 0.805, P = .047). For early onset preeclampsia, KRYPTOR area under the curve increased to 0.929 with a 100% specificity for preeclampsia at cut off 85 and an 88.9% sensitivity for preeclampsia at cut off 33. For women with preeclampsia and preterm delivery or Hemolysis, Elevated Liver enzymes, Low Platelet count (HELLP) syndrome, the KRYPTOR sFlt-1/PlGF ratio was manifold increased (P < .01). The sFlt-1/PlGF ratio proved especially useful in early onset preeclampsia, preeclampsia with preterm delivery or HELLP, and among non obese women. (C) 2015 American Society of Hypertension. All rights reserved.
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