Journal
EXPERIMENTAL EYE RESEARCH
Volume 90, Issue 6, Pages 655-663Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2010.02.014
Keywords
membrane-tethered mucins; MUC1; MUC4; MUC16; corneal epithelium; conjunctival epithelium; cell surface mucins
Categories
Funding
- NEI NIH HHS [R01 EY018850, R01 EY003306-30, R01 EY003306] Funding Source: Medline
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Membrane-tethered mucins are large glycoproteins present in the glycocalyx along the apical surface of all wet-surfaced epithelia of the body, including that of the ocular surface. Originally thought to function only in epithelial surface lubrication and hydration, data now indicate that the mucins are multifunctional molecules, each having unique as well as common functions. This review summarizes current knowledge regarding the three major membrane mucins of the ocular surface, MUC1, MUC4, and MUC16. The mucins vary in their ocular surface distribution, size, structural motifs, and functions. The ectodomains of each are released into the tear film and are, thus, a component of the soluble mucins of the tear film. Both animal and in vitro models for their study are herein described, as are alterations of the mucins in ocular surface disease. (C) 2010 Elsevier Ltd. All rights reserved.
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