Journal
EXPERIMENTAL EYE RESEARCH
Volume 88, Issue 4, Pages 837-844Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2008.11.003
Keywords
POAG; genetics; genetic linkage; whole genome association; admixture mapping; genetic screening; myocilin; optineurin; WDR36; SNP
Categories
Funding
- NEI NIH HHS [R01 EY015543, R01 EY023646, R03 EY014939] Funding Source: Medline
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Glaucoma is the major cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the United States. It has become increasingly clear that a host of genetic as well as environmental factors are likely to contribute to the phenotype. A number of chromosomal and genetic associations have been reported for POAG. This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease. (C) 2008 Elsevier Ltd. All rights reserved.
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