Journal
EXPERIMENTAL EYE RESEARCH
Volume 88, Issue 4, Pages 689-693Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2008.08.019
Keywords
fibronectin; trabecular meshwork; integrins; HepII domain
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Funding
- NIH-NEI [EY012515, EY017006, EY018274]
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Fibronectin plays a number of important roles in the extracellular matrix (ECM) including providing structural support and signaling cues for cell survival, migration, differentiation, gene expression, growth factor signaling, and cell contractility. In this review, we examine recent findings about the biological and structural properties of fibronectin and discuss how these properties could contribute to the regulation of aqueous humor (AH) outflow in the trabecular meshwork (TM). (C) 2008 Elsevier Ltd. All rights reserved.
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