Journal
EXPERIMENTAL EYE RESEARCH
Volume 88, Issue 4, Pages 676-682Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2008.11.023
Keywords
aqueous humor outflow resistance; extracellular matrix turnover; biosynthetic extracellular matrix; replacement
Categories
Funding
- NIH [EY003279, EY008247, EY010572]
- Glaucoma Research Foundation
- Research to Prevent Blindness, New York, NY
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Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM). This entails sensing elevated IOP, releasing numerous activated proteinases to degrade existing ECM and concurrent biosynthesis of replacement ECM components. To increase or decrease IOP, the quantity, physical properties and/or organization of new components should be somewhat different from those replaced in order to modify outflow resistance. ECM degradation and replacement biosynthesis in the outflow pathway must be tightly controlled and focused to retain the complex structural organization of the tissue. Recently identified podosome- or invadopodia-like structures (PILS) may aid in the focal degradation of ECM and organization of replacement components. (C) 2008 Elsevier Ltd. All rights reserved.
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