Journal
EXPERIMENTAL DIABETES RESEARCH
Volume -, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2008/271958
Keywords
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Funding
- Swedish Childhood Diabetes Foundation
- Malmo Branch of the Swedish Diabetes Association, Lions Club International District [101-S]
- Novo Nordisk Insulin Fund
- UMAS funds
- Terry & Louise Gregg Diabetes in Pregnancy Award from the American Diabetes Association
- Skane County Council Foundation for Research and Development
- Juvenile Diabetes Research Foundation
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Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
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