Journal
EXPERIMENTAL DERMATOLOGY
Volume 23, Issue 12, Pages 938-941Publisher
WILEY-BLACKWELL
DOI: 10.1111/exd.12563
Keywords
atopic dermatitis; Dermatophagoides farinae; IL-17A; IL-33; S100A8; S100A9
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Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI13C0010]
- Basic Science Research Program of the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2011-0016636]
- National Research Foundation of Korea [2011-0016636] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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S100A9 and S100A8 are called damage-associated molecular pattern (DAMP) molecules because of their pro-inflammatory properties. Few studies have evaluated S100A9 and S100A8 function as DAMP molecules in atopic dermatitis (AD). We investigated how house-dust mites affect S100A9 and S100A8 expression in Th2 cytokine- and Th17 cytokine-treated keratinocytes, and how secretion of these molecules affects keratinocyte-derived cytokines. Finally, we evaluated expression of these DAMP molecules in AD patients. S100A9 expression and S100A8 expression were strongly induced in IL-17A- and Dermatophagoides (D.) farinae-treated keratinocytes, respectively. Furthermore, co-treatment with D.farinae and IL-17A strongly increased expression of S100A9 and S100A8 compared with D.farinae-Th2 cytokine co-treatment. The IL-33 mRNA level increased in a dose-dependent manner in S100A9-treated keratinocytes, but TSLP expression did not change. S100A8/A9 levels were also higher in the lesional skin and serum of AD patients, and correlated with disease severity. Taken together, S100A9 and S100A8 may be involved in inducing DAMP-mediated inflammation in AD triggered by IL-17A and house-dust mites.
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