Journal
EXPERIMENTAL DERMATOLOGY
Volume 23, Issue 11, Pages 860-862Publisher
WILEY-BLACKWELL
DOI: 10.1111/exd.12531
Keywords
epidermal T cells; ginsenoside F1; interleukin 13; skin whitening
Categories
Funding
- National Research Foundation of Korea (NRF) - Korea government (MEST) [2012R1A1A1015784]
- National Research Foundation of Korea [2012R1A1A1015784] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Ginsenoside F1 (GF1) is a metabolite of ginsenoside Rg1. Although GF1 has several benefits for skin physiology, the effect of GF1 on skin pigmentation has not been reported. We found that a cream containing 0.1% GF1 showed a significant whitening effect on artificially tanned human skin after 8weeks of application. However, GF1 did not inhibit mRNA expression of tyrosinase or dopachrome tautomerase (DCT) in normal human epidermal melanocytes (NHEMs) or cocultured NHEMs/normal human epidermal keratinocytes. Interestingly, GF1 enhanced production of interleukin 13 (IL-13) from human epidermal T cells. IL-13 significantly reduced the mRNA expression and protein amount of both tyrosinase and DCT and reduced melanin synthesis activities in NHEMs, resulting in visible brightening of NHEM pellet. These results suggest that enhancement of IL-13 production by GF1 from epidermal T cells might play a role in the skin-whitening effect of GF1 via the suppression of tyrosinase and DCT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available