Journal
EXPERIMENTAL DERMATOLOGY
Volume 22, Issue 10, Pages 669-671Publisher
WILEY
DOI: 10.1111/exd.12222
Keywords
IL-31; itch; pruritogen; scratch; serotonin
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We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, over 1.5s) about 3h after administration followed by a gradual decrease for over 24h after administration. I.d. injection of IL-31 significantly increased the total LLS counts/24h but not short-lasting scratching (SLS, 0.3-1.5s). In skin-lesioned NC/Nga mice, the LLS but not SLS counts were significantly higher than those in non-skin-lesioned NC/Nga mice. We also investigated 5-HT-induced scratching in BALB/c mice, SLS but not LLS increased immediately after the injection and then decreased to baseline after at 20min. These results suggest that IL-31 may participate in the sensation of itching and promote scratching behaviour in skin-lesioned NC/Nga mice, an animal model of atopic dermatitis (AD).
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