Journal
EXPERIMENTAL DERMATOLOGY
Volume 22, Issue 11, Pages 757-759Publisher
WILEY
DOI: 10.1111/exd.12236
Keywords
lecithin retinol acyltransferase; melanoma; prognostic marker; RPE65; vitamin A
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Funding
- Hiege Foundation against Skin Cancer
- Olympia-Morata programme of the University Hospital Heidelberg
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Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P<0.001). In contrast, expression of LRAT was not significantly different (P=0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan-Meier analysis revealed earlier melanoma-related death (P=0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma.
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