Journal
EXPERIMENTAL DERMATOLOGY
Volume 22, Issue 3, Pages 219-221Publisher
WILEY
DOI: 10.1111/exd.12092
Keywords
atopic dermatitis; formaldehyde; house dust mite; NC/Nga mouse; proallergic cytokines
Categories
Funding
- Ministry for Health, Welfare & Family Affairs, Republic of Korea [A091121]
Ask authors/readers for more resources
Formaldehyde (FA) has been known to be associated with development of asthma (AS) and atopic dermatitis (AD). In this study, we investigated whether FA inhalation would affect the provocation or exacerbation of AD-like symptoms. Atopic-prone NC/Nga mice were exposed to low (0.2 ppm) and high (1.0 ppm) concentration of FA by inhalation. Combined exposure to low concentration of FA inhalation and topical house dust mite (HDM) stimulation significantly upregulated HDM-induced total plasma IgE and IgG2a production, Th1-, Th2-, Th17-related cytokine as well as COX-2 mRNA expressions in the skin. Interestingly, independent FA inhalation, especially at low concentration (0.2 ppm), increased the skin mRNA expressions of IL-13, IL-17E/IL-25 and COX-2, even though it failed to induce AD-like skin inflammation. In conclusion, we suggest that increased skin mRNA expressions of IL-13, IL-25/IL-17E and COX-2 by independent low concentration of FA exposure might be a key factor to exacerbate HDM-mediated AD-like skin inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available