Journal
EXPERIMENTAL DERMATOLOGY
Volume 21, Issue 8, Pages 581-585Publisher
WILEY
DOI: 10.1111/j.1600-0625.2012.01540.x
Keywords
chronic; in vivo; preclinical; translation; wound healing
Categories
Funding
- MRC [G0800004, G1000449] Funding Source: UKRI
- Medical Research Council [G0800004, G1000449] Funding Source: researchfish
- Medical Research Council [G1000449, G0800004] Funding Source: Medline
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Current understanding of the complex process of wound repair is based on decades of study. Integral to this understanding has been the use of in vitro and in vivo models to uncover the key molecular players. Now that major wound processes are more fully understood, therapeutic strategies can be developed to manipulate wound repair. Particularly important areas for future research include developing therapies to aid treatment of healing pathologies such as chronic wounds, and manipulating the normal healing processes to drive a more regenerative phenotype in adults. Here, we discuss the benefits and limitations of current animal-based models and highlight the urgent need for improved predictive preclinical models for wound healing research. We conclude by suggesting directions where more robust models of chronic wound pathologies may arise, expediting the development of novel therapies.
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