Journal
EXPERIMENTAL DERMATOLOGY
Volume 21, Issue 12, Pages 956-958Publisher
WILEY-BLACKWELL
DOI: 10.1111/exd.12033
Keywords
dermal papilla cell; extracellular histones; hair cycle; hair follicle
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Funding
- Korea Research Foundation (KRF)
- Korea government (MEST) [2012-001047]
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Release of histone H4 in rat vibrissa dermal papilla (DP) cells exposed to sub-toxic dose of colchicines has been recently reported. In addition, exposure to histone H4 has been reported to result in inhibited proliferation and reduced alkaline phosphatase (ALP) activity of cultured vibrissa DP cells. These findings prompted us to investigate the role of extracellular histones in hair growth using cultured human hair follicles and hair cycling using back skin of mice. We report here that exposure of cultured hair follicles to histone H4 and H2A resulted in significant inhibition of elongation of hair shafts, decreased expression of IGF-1 and decreased expression and activity of ALP. Injection of histones into hypodermis of mice during anagen resulted in premature onset of catagen. Findings of the current study provide strong evidence suggesting the inhibitory role of extracellular histones in hair growth.
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