Journal
EXPERIMENTAL DERMATOLOGY
Volume 20, Issue 12, Pages 959-968Publisher
WILEY
DOI: 10.1111/j.1600-0625.2011.01389.x
Keywords
hair follicle; innervation; pruritus; scalp
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Funding
- NIH [RO-1AR55902-3, Ro-11R01AR055902-03A1]
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Scalp pruritus is a common complaint that is considered a diagnostically and therapeutically challenging situation. Scalp skin has a unique neural structure that contains densely innervated hair follicles and dermal vasculature. In spite of the recent advances in our understanding of itch pathophysiology, scalp itching has not been studied as yet. In this review, we summarize the current knowledge on the neurobiology of scalp and hair follicles as well as itch mediators and provide a putative mechanism for scalp itch with special emphasis on neuroanatomy and pathophysiology.
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