Journal
EXPERIMENTAL DERMATOLOGY
Volume 17, Issue 9, Pages 788-789Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0625.2008.00707.x
Keywords
collagen gel contraction; human dermal fibroblasts; tensin1
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As revealed by immunohistochemistry and RT-QPCR, the focal adhesion protein tensin1 is expressed in cultured human dermal fibroblasts and reduced by 60% after transfection with tensin1 siRNA. Tensin1 silenced fibroblast exhibited a strongly reduced capacity to contract collagen gels. Aged fibroblasts, generated with the Hayflick replicative senescence model, exhibit as siRNA silences fibroblasts, a reduced tensin1 expression and an impaired gel contraction capacity. Based on these results, we speculate that in human dermal fibroblasts, tensin1 plays an important role in cell-matrix interaction and that a reduced expression might contribute to the dermal alterations observed during skin ageing.
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