Journal
EXPERIMENTAL CELL RESEARCH
Volume 324, Issue 1, Pages 84-91Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.03.017
Keywords
STI1; Rnd1; Hop; Neuritogenesis
Categories
Funding
- CNPq [572068/2008-5, 479070/2010-5]
- Fundacao Araucaria [22509, 35121]
- SETI-UGF [87/07]
- INCT-Redoxoma [573530/2008-4]
- CAPES
- CNPq-PIBIC fellowship
Ask authors/readers for more resources
Rnd proteins comprise a branch of the Rho family of small GTP-binding proteins, which have been implicated in rearrangements of the actin cytoskeleton and microtubule dynamics. Particularly in the nervous system, Rnd family proteins regulate neurite formation, dendrite development and axonal branching. A secreted form of the co-chaperone Stress-Inducible Protein 1 (STI1) has been described as a prion protein partner that is involved in several processes of the nervous system, such as neurite outgrowth, neuroprotection, astrocyte development, and the self-renewal of neural progenitor cells. We show that cytoplasmic STI1 directly interacts with the GTPase Rnd1. This interaction is specific for the Rnd1 member of the Rnd family. In the COS collapse assay, overexpression of STI1 prevents Rnd1 plexin-A1-mediated cytoskeleton retraction. In PC-12 cells, overexpression of STI1 enhances neurite outgrowth in cellular processes initially established by Rnd1. Therefore, we propose that STI1 participates in Rnd1-induced signal transduction pathways that are involved in the dynamics of the actin cytoskeleton. (C) 2014 Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available