Journal
EXPERIMENTAL CELL RESEARCH
Volume 328, Issue 2, Pages 284-295Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.09.005
Keywords
Planar cell polarity; Wnt signaling; Cilium; Contratility; Diseases
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Funding
- INSERM
- Institut Paoli-Calmettes
- La Ligue Nationale Contre le Cancer (Equipe labellisee)
- INCa (Project Libre INCa)
- SIRIC program [INCa-DGOS-Inserm 6038]
- ARC association (Projet Fondation ARC)
- Institut Universitaire de France
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Planar cell polarity or PCP refers to a uniform cellular organization within the plan, typically orthogonal to the apico-basal polarity axis. As such, PCP provides directional cues that control and coordinate the integration of cells in tissues to build a living organism. Although dysfunctions of this fundamental cellular process have been convincingly linked to the etiology of various pathologies such as cancer and developmental defects, the molecular mechanisms governing its establishment and maintenance remain poorly understood. Here, we review some aspects of invertebrate and vertebrate PCPs, highlighting similarities and differences, and discuss the prevalence of the non-canonical Wnt signaling as a central PCP pathway, as well as recent findings on the importance of cell contractility and cilia as promising avenues of investigation. (C) 2014 Elsevier Inc. All rights reserved.
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