Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 15, Pages 2350-2359Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.07.022
Keywords
Angiogenesis; Cerebral cavernous malformations; Endothelial junctions; Vasculogenesis; Contractility
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Funding
- NHLB1 grant [HL111582]
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Rap1 signaling is important for both major processes of vessel formation: vasculogenesis, or de nova vessel formation, and angiogenesis, sprouting of new vessels from pre-existing ones. We provide an overview of genetic studies in mice and zebrafish and discuss some of the proposed underlying mechanisms derived from cellular models, with particular emphasis on Rap1's role in angiogenesis, maintenance of endothelial barrier and connection with cerebral cavernous malformation (CCM), a neurological deficit that leads to seizures and lethal stroke. Lastly, we provide a brief summary of studies in cardiac and smooth muscle cells, where the Epac-Rap1 signaling axis is emerging as an important regulator of contractility. (C) 2013 Elsevier Inc. All rights reserved.
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