Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 15, Pages 2316-2322Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.03.024
Keywords
Arl; Small GTPase; Ciliopathy; Cilia
Categories
Funding
- National Institutes of Health [1R01DK090038]
- P30 center grant [P30DK90728]
- Mayo Clinic Center for Cell Signaling in Gastroenterology [P30DK084567]
- PKD Foundation Young Investigator Award [04YI09a]
- National Cancer Institute (NCI) [1R01CA149039-01A1]
- Susan G. Komen for the Cure [KG100902]
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The primary cilia are microtubule-based organelles that protrude from most of the eukaryotic cells. Recognized as the cell's antenna, primary cilium functions as a signaling hub for many physiologically and developmentally important signaling cascades. Ciliary dysfunction causes a wide spectrum of syndromic human genetic diseases collectively termed ciliopathies. Mounting evidences have shown that various small GTPases have been implicated in the context of cilia as well as human ciliopathies. However, how these small GTPases affect cilia formation and function remains poorly understood. Here we review and discuss the ciliary role of three Arf-like small GTPases (Arls), Ar13, ArI6, and Ar113b. (C) 2013 Elsevier Inc. All rights reserved.
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