Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 11, Pages 1650-1656Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.03.006
Keywords
Cancer; Fibroblasts; Tumor microenvironment; Mesenchyme; Carcinogenesis
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Funding
- NIGMS NIH HHS [T32 GM008224] Funding Source: Medline
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Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy. (c) 2013 Elsevier Inc. All rights reserved.
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