Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 10, Pages 1357-1364Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.03.021
Keywords
Epithelia; Cell polarity; Apical; Basolateral; Par complex; Adhesion forces
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Funding
- Research Grants Council of Hong Kong [663610, 663811, 663812, HKUST6/CRF/10, SEG_HKUST06, T13-607/12R]
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Apical-basal polarity is the basic organizing principle of epithelial cells, and endows epithelial cells to function as defensive barriers and as mediators of vectorial transport of nutrients in and out of organisms. Apical-basal polarity is controlled by a number of conserved polarity factors that regulate cytoskeletal organizations, asymmetric distributions of cellular components, and directional transports across cells. Polarity factors often occupy specific membrane regions in response to the adhesion forces generated by cell-cell and cell-extracellular matrix interactions. Both internal polarity factors and the external extracellular matrices play fundamental roles in epithelial cell polarity establishment and maintenance. This review focuses on recent developments of the Par3/Par6/aPKC complex and its interacting proteins in epithelial cell polarity. (C) 2013 Elsevier Inc. All rights reserved.
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