Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 9, Pages 1348-1355Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.02.021
Keywords
PI3K; AKT; FOXOs; Endothelial cells; Angiogenesis
Categories
Funding
- Spanish Govern [SAF2010-15661]
- Ajuts loves Investigators from IDIBELL
- Max Planck Society
- Deutsche Forschungsgemeinschaft [SFB 834]
- Cluster of Excellence Macromolecular Complexes [EXC115]
- Excellence Cluster Cardiopulmonary System [EXC 147/1]
- Foundation Leducq Transatlantic Network ARTEMIS
- European Research Council Starting Grant [ANGIOMET]
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Phosphoinositide 3-kinases (PI3Ks) are an evolutionary conserved family of lipid kinases that control cell growth, metabolism and survival. By generating lipid second messengers that interact with specialized lipid-binding domains found in a wide spectrum of signaling molecules, PI3Ks instigate signaling through a network of downstream effector pathways. Genetic studies in zebrafish and mice revealed the critical importance of intact PI3K signaling in the endothelium and provided first insights into how individual PI3K isoforms are utilized to control vascular development and function. Here, we review the myriad roles of PI3Ks in the endothelium and the mechanisms through which they couple environmental signals with specific steps of angiogenic vessel growth. (C) 2013 Elsevier Inc. All rights reserved.
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