Journal
EXPERIMENTAL CELL RESEARCH
Volume 319, Issue 20, Pages 3094-3103Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.08.018
Keywords
Migration; Proliferation; Cytokinesis; Melanoma; Mesothelioma; Lung cancer
Categories
Funding
- Hungarian Science Foundation [OTKA-MOB-80325, OTKA K 108465, OTKA K72664]
- Initiative Krebsforschung of the Medical University Vienna
- KTIA AIK [12-1-2013-0041]
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The mortality of patients with solid tumors is mostly due to metastasis that relies on the interplay between migration and proliferation. The go or grow hypothesis postulates that migration and proliferation spatiotemporally excludes each other. We evaluated this hypothesis on 35 cell lines (12 mesothelioma, 13 melanoma and 10 lung cancer) on both the individual cell and population levels. Following three-day-long videomicroscopy, migration, proliferation and cytokinesis-length were quantified. We found a significantly higher migration in mesothelioma cells compared to melanoma and lung cancer while tumor types did not differ in mean proliferation or duration of cytokinesis. Strikingly, we found in melanoma and lung cancer a significant positive correlation between mean proliferation and migration. Furthermore, non-dividing melanoma and lung cancer cells displayed slower migration. In contrast, in mesothelioma there were no such correlations. Interestingly, negative correlation was found between cytokinesis-length and migration in melanoma. FAK activation was higher in melanoma cells with high motility. We demonstrate that the cancer cells studied do not defer proliferation for migration. Of note, tumor cells from various organ systems may differently regulate migration and proliferation. Furthermore, our data is in line with the observation of pathologists that highly proliferative tumors are often highly invasive. (C) 2013 Elsevier Inc. All rights reserved.
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