Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 11, Pages 1269-1277Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.04.005
Keywords
Apoptosis; Necroptosis; DISC; FADD; Caspase-8; RIPK; cFLIP
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Funding
- UK Medical Research Council
- Medical Research Council [MC_U132685863] Funding Source: researchfish
- MRC [MC_U132685863] Funding Source: UKRI
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Cell death is critical to the normal functioning of multi-cellular organisms, playing a central role in development, immunity, inflammation, and cancer progression. Two cell death mechanisms, apoptosis and necroptosis, are dependent on the formation of distinct multi-protein complexes including the DISC, Apoptosome, Piddosome and Necrosome following the induction of cell death by specific stimuli. The role of several of these key multi-protein signalling platforms, namely the DISC, TNFR1 complex I/II, the Necrosome and Ripoptosome, in mediating these pathways will be discussed, as well as the open questions and potential therapeutic benefits of understanding their underlying mechanisms. (C) 2012 Elsevier Inc. All rights reserved.
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