Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 12, Pages 1340-1346Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.02.018
Keywords
Meiosis; Synaptonemal complex; Mammals
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Funding
- DFG [Be1168/7-2]
- Graduate School (Organogenesis) of the University of Wurzburg [1048]
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The synaptonemal complex (SC) is a proteinaceous structure of chromosome bivalents whose assembly is indispensable for the successful progression of the first meiotic division of sexually reproducing organisms. In this mini-review we will focus on recent progress dealing with the composition and assembly of the mammalian SC. These advances mainly resulted from the systematic use of knockout mice for all known mammalian SC proteins as well as from protein polymerization studies performed in heterologous systems. (c) 2012 Elsevier Inc. All rights reserved.
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