Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 9, Pages 1057-1067Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.02.026
Keywords
Renal cell cancer; VHL tumor suppressor; Hypoxia-inducible factor; Oxygen; Glucose metabolism; Mitochondria
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Funding
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Cancer Institute (NCI)
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Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis. (C) 2012 Elsevier Inc. All rights reserved.
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