Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 12, Pages 1400-1406Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.04.006
Keywords
Spindle orientation; Kar9 pathway; Dynein; Spindle position checkpoint
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Funding
- UMass Commonwealth College Undergraduate Research Assistantship
- NIH [1R01GM076094]
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Cortical force generators play a central role in the orientation and positioning of the mitotic spindle. In higher eukaryotes, asymmetrically localized cortical polarity determinants recruit or activate such force generators, which, through interactions with astral microtubules, position the mitotic spindle at the future site of cytokinesis. Recent studies in budding yeast have shown that, rather than the cell cortex, the astral microtubules themselves may provide polarity cues that are needed for asymmetric pulling on the mitotic spindle. Such asymmetry has been shown to be required for proper spindle positioning, and consequently faithful and accurate chromosome segregation. In this review, we highlight results that have shed light on spindle orientation in this classical model of asymmetric cell division, and review findings that may shed light on similar processes in higher eukaryotes. (c) 2012 Elsevier Inc. All rights reserved.
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